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KMID : 0363819770110010017
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Korean Journal of Nuclear Medicine
1977 Volume.11 No. 1 p.17 ~ p.32
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A Study of the Insulin and the C-Peptide Responses to Oral Glucose Load in Nondiabetic and Diabetic Subjects
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李明哲/Lee, Myung Chul
崔成在/金應振/閔獻基/高昌舜/Choi, Sung Jae/Kim, Eung Jin/Koh, Chang-Soon/Min, Hun Ki
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Abstract
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The present study was undertaken to evaluate the significance of the insulin and the C-peptide rseponse to oral glucose loads in normal and diabetic subjects and to establish the effects of the obesity.
In this study, the authors have measured plasma insulin and C-peptide by means of radioimmunoassay in 10 nonobese normal, 5 obese normal, 13 nonobese moderate diabetic patients, 9 obese moderate diabetic patients and 9 severe diabetic patients.
The results obtained were as follows;
1. In 10 nonobese normal subjects, the plasma insulin level at fasting state and at 30, 60, 90, and 120 min after oral glucose loads were 15.7±3.4, 48.3±9.8, 40. 4±6. 7, 37. 4±6. 5 and 26. 0 ±4.2 uU/ml(Mean±S.E.) and C-peptide were 1.9±0.3, 3.9±0.6, 6.3±0.6, 5.7±0.5 and 4.0± 0. 5ng/ml. The change of C-peptide was found to go almost parallel with that of insulin and the insulin value´ reaches to the highest level at 30 min whereas C-peptide reaches to its peak at 60min.
2. The plasma insulin level in 5 obese normal subjects were 38.9±12.3, 59.5:L-12.3, 59.2± 17.1, 56.1±20.0 and 48.4±17.2 uU/ml and the C-peptide were 5.5±0.4, 6.8±0.5, 7.9±0.8, 7. 9±0.8 and 7.8±2.Ong/ml. The insulin response appeared to be greater than ;nonobese normal subjects.
3. In 13 nonobese moderate diabetic patients, the plasma insulin levels were 27.1±4.9, 44.1--46.0, 37.3±6.6, 35.5±8.1 and 34.7±10.7uU/ml and the C-peptide levels were 2.7±0.4, 4.940. 7, 6. 5±0. 5,7.0±0.3 and 6.7±1. 0 ng/ ml. There was little significance compared to nonobese normal groups but delayed pattern is noted.
4. In 9 obese moderated diabetic patients, the plasma insulin levels were 22. 1±7. 9, 80.0±19.3, 108. 0±27. 0, 62.0±17.6 and 55.5±10. 1 uU/ml and the C-peptide levels were 5. 2±0. 4, 8. 0±1.0, 10. 4±1. 6, 10.4±1.7,and 10. 1 ± 1. Ong/ml and its response was also greater than that of nonobese moderate diabetic patients.
5. The plasma insulin concentrations in 9 severe diabetic subjects were 8. 0±3. 8, 12. 1±3. 5, 16. 8±4. 6, 19.6±5.2 and 15. 0±5.0 uU/ml and the C-peptide levels were 1. 6±0. 3, 2. 4±0. 4,
4. 1±0. 6, 4.0±0.8 and 4.5±0.7ng/ml and the insulin and C-peptide responses were markedly redo^ed in severe diabetic groups.
6. There were significant differences between each groups of patients on the magnitude of total insulin or C-peptide areas, the insulinogenic index and the C-peptide index.
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KEYWORD
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